ea0010p26 | Cytokines, growth factors, growth and development | SFE2005
Ahmed Z
, Mazibrada G
, Dent R
, Berry M
, Logan A
Upon binding of myelin-derived axon growth inhibitory ligands to the Nogo receptor (NgR), a complex is formed with LINGO-1 and the low affinity neurotrophin receptor p75NTR, which initiates axon growth cone collapse via a Rho-A-mediated pathway. We reasoned that, after tumor necrosis factor-α converting enzyme (TACE) cleavage of p75NTR, which triggers the initiation of regulated intramembrane proteolysis (RIP), signalling of growth cone collap...